1 |
 SpaceX |
Elon Musk |
Hawthorne, CA |
2002 |
Space |
Designs, manufactures, and launches advanced rockets and spacecraft |
2 |
 OpenAI |
Sam Altman |
San Francisco, CA |
2015 |
Artificial Intelligence |
AI research and deployment, with a goal of building artificial general intelligence |
3 |
 Blue Origin |
Bob Smith |
Kirkland, WA |
2000 |
Space |
Reusable launch vehicles utilizing rocket-powered vertical take-off and vertical landing technology |
4 |
Northvolt |
Peter Carlsson |
Stockholm, Sweden |
2016 |
Climate |
Lithium-ion battery plants intended to produce batteries for electric vehicles |
5 |
 Impossible Foods |
Peter McGuinness |
Redwood City, CA |
2011 |
Agriculture |
Plant-based meat |
6 |
 Anduril |
Brian Schimpf |
Irvine, CA |
2017 |
Aviation/Drones |
Autonomous hardware and software for the national security sector |
7 |
 Nuro |
Jiajun Zhu |
Mountain View, CA |
2016 |
Mobility/Autonomous Vehicles |
Self-driving vehicles |
8 |
 Sila Nanotechnologies |
Gene Berdichevsky |
Alameda, CA |
2011 |
Climate |
Higher energy density lithium-ion batteries for electric vehicles |
9 |
 Anthropic |
Dario Amodei |
San Francisco, CA |
2021 |
Artificial Intelligence |
AI safety and research to create large-scale AI systems that are steerable, interpretable, and robust |
10 |
 Indigo Ag |
Ron Hovsepian |
Boston, MA |
2013 |
Agriculture |
Plant agricultural services to increase crop yield through their biologicals business, scope 3 sustainable grains program, and carbon program |
11 |
 Carbon |
Phil DeSimone and Craig Carlson |
Redwood City, CA |
2013 |
Robotics |
Industrial 3D printing |
12 |
 Pony |
James Peng |
Fremont, CA and Beijing, China |
2016 |
Mobility/Autonomous Vehicles |
Full-stack robotaxis |
13 |
 Zipline |
Keller Rinaudo Cliffton |
San Francisco, CA |
2014 |
Aviation/Drones |
Drones to deliver vital medical products to everyone |
14 |
 TerraPower |
Chris Levesque |
Seattle, WA |
2009 |
Climate |
Sodium fast reactor for nuclear fission |
15 |
 Geek+ |
Yong Zheng |
Beijing, China |
2015 |
Robotics |
Robotics technology for logistics and warehouse automation |
16 |
 Inari |
Drew Hykes |
Cambridge, MA |
2016 |
Agriculture |
Plant breeding platform |
17 |
 Formlabs |
Maxim Lobovsky |
Somverville, MA |
2011 |
Robotics |
3D printers for engineers, designers, and manufacturers |
18 |
 Zeekr |
Andy An |
Ningbo, China |
2021 |
Mobility/Autonomous Vehicles |
Electric mobility technology and solutions for premium electric vehicles |
19 |
 OLA Electric |
Bhavish Aggarwal |
Bangalore, India |
2017 |
Mobility/Autonomous Vehicles |
Electric mobility platform for shared daily mobility solutions |
20 |
 PathAI |
Andrew Beck |
Boston, MA |
2016 |
Next-gen biotech |
AI-powered research platform designed to improve the accuracy and efficiency of cancer diagnosis and treatment |
21 |
 Commonwealth Fusion Systems |
Bob Mumgaard |
Devens, MA |
2018 |
Climate |
Fusion energy systems |
22 |
 Pivot Bio |
Karsten Temme |
Berkeley, CA |
2010 |
Agriculture |
Microbial nitrogen fertilizers to replace synthetic nitrogen fertilizer |
23 |
 Character.AI |
Noam Shazeer |
Menlo Park, CA |
2021 |
Artificial Intelligence |
Open-ended conversational chatbots using generative AI |
24 |
 Shield AI |
Ryan Tseng |
San Diego, CA |
2015 |
Aviation/Drones |
Defense drones |
25 |
 Factorial Energy |
Siyu Huang |
Woburn, MA |
2013 |
Climate |
Nano-engineered batteries intended for electric vehicles, homes, and critical applications |
26 |
 Graphcore |
Nigel Toon |
Bristol, UK |
2016 |
Artificial Intelligence |
Intelligence processing unit designed for machine intelligence workloads |
27 |
 Redwood Materials |
J. B. Straubel |
Carson City, NV |
2017 |
Climate |
Battery recycling for electric vehicles and sustainable materials |
28 |
 Altos Labs |
Hal Barron |
Redwood City, CA |
2021 |
Next-gen biotech |
Cellular rejuvenation programming to reverse disease, injury, and the disabilities that can occur throughout life |
29 |
 Climeworks |
Jan Wurzbacher and Christoph Gebald |
Zurich, Switzerland |
2009 |
Climate |
Carbon direct air capture and recycling / removal |
30 |
 Eikon Therapeutics |
Roger Perlmutter |
Hayward, CA |
2019 |
Next-gen biotech |
Drug discovery platform |
31 |
 Skydio |
Adam Bry |
Redwood City, CA |
2014 |
Aviation/Drones |
Advanced drone manufacturer |
32 |
 Solugen |
Gaurab Chakrabarti |
Houston, TX |
2016 |
Climate |
Molecular development platform to replace petroleum-based products with plant-derived substitutes |
33 |
 Einride |
Robert Falck |
Stockholm, Sweden |
2016 |
Mobility/Autonomous Vehicles |
Electric and self-driving vehicles |
34 |
 Our Next Energy |
Mujeeb Ijaz |
Novi, MI |
2020 |
Climate |
Advanced batteries to improve energy density and safety while lowering costs for mobility and grid storage applications |
35 |
 Inflection.AI |
Mustafa Suleyman |
Palo Alto, CA |
2022 |
Artificial Intelligence |
Artificial intelligence-based platform designed to improve human-computer interaction. |
36 |
 Perfect Day |
Ryan Pandya |
Emeryville, CA |
2014 |
Agriculture |
Animal-free milk substitutes |
37 |
 Upside Foods |
Uma Valeti |
San Leandro, CA |
2015 |
Agriculture |
Cell-based meat |
38 |
 Group14 Technologies |
Rick Luebbe |
Woodinville, WA |
2015 |
Climate |
Advanced silicon-carbon technology intended to enable the electrification of everything |
39 |
 Form Energy |
Mateo Jaramillo |
Somerville, MA |
2017 |
Climate |
Iron-air batteries for multi-day energy storage |
40 |
 Insitro |
Daphne Koller |
San Francisco, CA |
2018 |
Next-gen biotech |
Data-driven drug discovery and development |
41 |
 Cohere |
Aidan Gomez |
Toronto, Canada |
2019 |
Artificial Intelligence |
Natural language processing software to build machines that understand the world and make them safely accessible to all |
42 |
 Fabric |
Avi (Jack) Jacoby |
New York, NY |
2015 |
Robotics |
On-demand fulfillment centers for cities |
43 |
 Cerebras Systems |
Andrew Feldman |
Sunnyvale, CA |
2016 |
Artificial Intelligence |
Computing chips to accelerate AI development |
44 |
 Locus Robotics |
Rick Faulk |
Wilmington, MA |
2014 |
Robotics |
Autonomous mobile robots intended to simplify and automate warehouse and e-commerce operations |
45 |
 NotCo |
Matias Muchnick |
Santiago, Chile |
2015 |
Agriculture |
Plant-based food |
46 |
 Sierra Space |
Tom Vice |
Louisville, CO |
2021 |
Space |
Commercial space transportation |
47 |
 Monolith Materials |
Rob Hanson |
Lincoln, NE |
2012 |
Climate |
Converting natural gas to carbon black and hydrogen |
48 |
 Nexii |
Stephen Sidwell |
Vancouver, Canada |
2018 |
Climate |
High-performance buildings and green building products |
49 |
 Eat Just |
Josh Tetrick |
San Francisco, CA |
2011 |
Agriculture |
Plant-based egg products |
50 |
 Exotec |
Romain Moulin |
Croix, France |
2015 |
Robotics |
Collaborative mobile robots to transport and sort logistics in warehouses |
51 |
 Innovafeed |
Clément Ray |
Paris, France |
2016 |
Agriculture |
Insect-based protein |
52 |
 Nature's Fynd |
Thomas Jonas |
Chicago, IL |
2012 |
Agriculture |
Microbe-based protein |
53 |
 Icon Build |
Jason Ballard |
Austin, TX |
2017 |
Robotics |
Construction technology to build 3D-printed homes |
54 |
 Svante Technologies |
Claude Letourneau |
Burnaby, Canada |
2007 |
Climate |
Adsorption technology to capture post-combustion industrial and power plant flue gas |
55 |
 Generate Biomedicines |
Mike Nally |
Cambridge, MA |
2018 |
Next-gen biotech |
Generative biology platform intended to invent new drugs across protein modalities and protein therapeutics |
56 |
 Opentrons |
Jonathan Brennan-Badal |
Brooklyn, NY |
2013 |
Robotics |
Robotic automation for medical labs |
57 |
 SambaNova |
Rodrigo Liang |
Palo Alto, CA |
2017 |
Artificial Intelligence |
Advanced systems platform and hardware designed to power machine learning |
58 |
 Astranis |
John Gedmark |
San Francisco, CA |
2015 |
Space |
Small and low-cost telecommunications satellites to provide internet access in remote regions |
59 |
 Tessera Therapeutics |
Michael Severino |
Cambridge, MA |
2018 |
Next-gen biotech |
Gene writing technology |
60 |
 Covariant |
Peter Chen |
Emeryville, CA |
2017 |
Robotics |
AI and robotics platform |
61 |
 Inscripta |
Sri Kosaraju |
Boulder, CO |
2015 |
Next-gen biotech |
Gene-editing platform |
62 |
 PaigeAI |
Andy Moye |
New York, NY |
2017 |
Next-gen biotech |
Computational pathology platform for rapid diagnostics |
63 |
 AMP Robotics |
Matanya Horowitz |
Louisville, CO |
2015 |
Robotics |
Advanced recycling robotics |
64 |
 Relativity Space |
Tim Ellis |
Long Beach, CA |
2015 |
Space |
3D printed rockets |
65 |
 Standard AI |
Jordan Fisher |
San Francisco, CA |
2016 |
Robotics |
Autonomous checkout technology |
66 |
 HawkEye 360 |
John Serafini |
Herndon, VA |
2015 |
Space |
Space-based radio frequency technology for geospatial data analytics |
67 |
 PsiQuantum |
Jeremy O'Brien |
Palo Alto, CA |
2016 |
Quantum |
Building a large-scale, general-purpose silicon photonic quantum computer |
68 |
 H2 Green Steel |
Henrik Henriksson |
Stockholm, Sweden |
2020 |
Climate |
Green steel production |
69 |
 Helion Energy |
David Kirtley |
Everett, WA |
2013 |
Climate |
Aneutronic fusion power |
70 |
 Believer |
Nicole Johnson-Hoffman |
Rehovot, Israel |
2018 |
Agriculture |
Plant-based food and cellular agriculture |
71 |
 UISEE |
Gansha Wu |
Beijing, China |
2016 |
Mobility/Autonomous Vehicles |
AI and advanced sensors for AV autonomy stack |
72 |
 Valo Health |
David Berry |
Boston, MA |
2019 |
Next-gen biotech |
Data-driven drug discovery and development |
73 |
 UBQ Materials |
Jack Bigio |
Tel Aviv, Israel |
2012 |
Climate |
Alternative plastics |
74 |
 Freenome |
Mike Nolan |
San Francisco, CA |
2014 |
Next-gen biotech |
Multi-omics platform designed to detect cancer through a routine blood draw |
75 |
 Voi |
Fredrik Hjelm |
Stockholm, Sweden |
2018 |
Mobility/Autonomous Vehicles |
E-scooters |
76 |
 BioSplice |
Cevdet Samikoglu |
San Diego, CA |
2008 |
Next-gen biotech |
Medical research and development for tissue-level regeneration |
77 |
 ICEYE |
Rafal Modrzewski |
Espoo, Finland |
2012 |
Space |
Radar satellite imaging |
78 |
 Wayve |
Alex Kendall |
London, UK |
2017 |
Mobility/Autonomous Vehicles |
Autonomous vehicles on public roads with end-to-end deep learning |
79 |
 Agile Robots |
Zhaopeng Chen |
Munich, Germany |
2018 |
Robotics |
Robotic technology designed to offer full-body force sensitivity and vision intelligence-based systems |
80 |
 TAE Technologies |
Michl Binderbauer |
Foothill Ranch, CA |
1998 |
Climate |
Aneutronic fusion power |
81 |
 Meati Foods |
Tyler Huggins |
Boulder, CO |
2014 |
Food/Agriculture |
Fungi-based steak |
82 |
 The Every Company |
Arturo Elizondo |
San Francisco, CA |
2014 |
Agriculture |
Animal-free protein and smoothies |
83 |
 Groq |
Jonathan Ross |
Mountain View, CA |
2016 |
Artificial Intelligence |
AI-tailored semiconductor chips |
84 |
 Spiber |
Kazuhide Sekiyama |
Yamagata, Japan |
2007 |
Next-gen biotech |
Plant and fermentation-based biomaterial, Brewed Protein™ materials |
85 |
 Ample |
Khaled Hassounah |
San Francisco, CA |
2014 |
Robotics |
Autonomous robotics for electric car battery swapping |
86 |
 SparkCognition |
Amir Husain |
Austin, TX |
2013 |
Artificial Intelligence |
AI/ML solutions across defense, IoT, and finance industries |
87 |
 Forever Oceans |
Bill Bien |
Gainesville, VA |
2014 |
Food/Agriculture |
Offshore aquaculture farms |
88 |
 Bowery Farming |
Irving Fain |
New York, NY |
2014 |
Agriculture |
CV + automation to monitor plants and their growth |
89 |
 XtalPi |
Ma Jian |
Cambridge,MA / Beijing, China |
2014 |
Next-gen biotech |
Quantum physics and artificial intelligence for drug discovery and development |
90 |
 Lightmatter |
Nick Harris |
Boston, MA |
2017 |
Artificial Intelligence |
AI chip using integrated optical technology |
91 |
 Colossal Biosciences |
Ben Lamm |
Austin, TX |
2020 |
Next-gen biotech |
Extinct species restoration, critically endangered species protection, and the repopulation of critical ecosystems that support the continuation of life on Earth |
92 |
 Xanadu |
Christian Weedbrook |
Toronto, Canada |
2016 |
Quantum |
Photonic-based quantum computer |
93 |
 Ynsect |
Antoine Hubert |
Paris, France |
2011 |
Agriculture |
Insect vertical farms intended to produce premium organic alternative proteins and fertilizer from insects |
94 |
 Boom |
Blake Scholl |
Englewood, CO |
2014 |
Aviation/Drones |
Supersonic passenger flight |
95 |
 DroneDeploy |
Michael Winn |
San Francisco, CA |
2013 |
Aviation/Drones |
Drone data platform to help businesses collect, manage, and interpret drone data |
96 |
 Beta Technologies |
Kyle Clark |
South Burlington, VT |
2012 |
Aviation/Drones |
Electric vertical takeoff and landing aircraft and recharging pad systems |
97 |
 Bolt Threads |
Dan Widmaier |
Emeryville, CA |
2009 |
Agriculture |
Textile fibers using biotechnology and fermentation |
98 |
 ElevateBio |
David Hallal |
Waltham, MA |
2017 |
Next-gen biotech |
Cell and gene therapy companies intended to develop, manufacture and commercialize life-transforming medicines |
99 |
 Mammoth Biosciences |
Trevor Martin |
Brisbane, CA |
2017 |
Next-gen biotech |
CRISPR-based detection platform intended to democratize disease detection |
100 |
 Arsenal Bio |
Ken Drazan |
San Francisco, CA |
2019 |
Next-gen biotech |
Cellular drug discovery tools designed to provide medicines for cancer treatment |